Assessing Mucin16+ ovarian tumor models with standards of care

Tumor Models Summit 2025 -- Ovarian cancer, a formidable gynecological malignancy, poses a significant threat to women's health worldwide. Its nature often leads to late-stage diagnosis, contributing to poor prognosis and limited treatment options. The NIH:OVCAR-3 cell line stands out as a widely utilized and well-characterized model in this research. Derived from a patient with metastatic ovarian adenocarcinoma, NIH:OVCAR-3 cells exhibit characteristics representative of high-grade serous ovarian carcinoma, the most common and aggressive subtype. An ovarian patient derived xenograft (PDX) model, LCOV-2089 is derived from a patient with ovarian adenocarcinoma. The model is derived from an ovary biopsy.