Understanding the disposition of your molecule and its drug metabolism & pharmacokinetic (DMPK) profile is critical to making the right decisions about your molecule and minimizing failures at every stage of development. Whether you're optimizing lead candidates, preparing for IND-enabling studies or managing clinical-stage assets, you need actionable data from reliable Absorption, Distribution, Metabolism, and Excretion (ADME) studies to guide you forward in a cost- and time-efficient way. Don’t get surprised by poor clinical exposure or a drug-drug interaction that can slow or halt the development of your small molecule, large molecule or biologic based pharmaceutical candidate.
Multidisciplinary team with years of experience
Flexible solutions to meet any development strategy
Programmatic metabolism model to save time and minimize failure
Our DMPK support is designed to give you clear insight into your molecule's biotransformation and pharmacokinetic behavior. Using in vitro and in vivo metabolism studies, we help you:
Whether you need bioanalytical support, PBPK modeling or comprehensive ADME studies, our scientists work alongside your team to build a customized strategy that aligns with your development goals.
With the right data, you can move faster, reduce risk and make critical decisions with confidence.
PK studies help determine how a drug behaves in the body, which is crucial for determining dosing, safety and efficacy. Labcorp's PK services support all phases of drug development, from discovery to clinical studies.
Common methods include blood sampling, urine collection and tissue analysis to measure drug concentrations over time. Labcorp utilizes advanced bioanalytical techniques and validated assays for accurate PK profiling.
DDIs are typically identified through in vitro studies, clinical trials and post-marketing surveillance. Labcorp offers a range of in vitro DDI assays, including CYP inhibition and induction studies, as well as support for clinical DDI trials.
Key considerations include selecting appropriate sampling times, choosing relevant biomarkers, determining sample size and accounting for potential sources of variability. Labcorp's experienced scientists can assist in designing robust PK studies tailored to specific drug candidates and development needs.
DMPK studies help identify potential safety issues by providing information on drug exposure, metabolism and potential toxic metabolites. Labcorp's integrated approach to DMPK and toxicology studies helps clients assess drug safety comprehensively.
