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Antibody-Drug Conjugates (ADCs)

Realizing the full potential of ADCs requires deep understanding of their nuances. With extensive ADC experience and a global footprint, we provide crucial support from discovery through post-commercialization.
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What is an ADC?

An ADC is a therapy designed to target specific cells in the body. It consists of a monoclonal or bispecific antibody connected to a cytotoxic agent via a chemical linker. This modality enables precise targeting of diseased cells while sparing normal tissues to maximize a treatment's effectiveness against disease while minimizing adverse side effects. 

Our deep and evolving ADC experience

83%

Supported 15 of the 18 approved ADCs currently available on the global market

77%

Supporting 13 of the 17 mid- to late-stage clinical trial ADCs currently in development

Experience

with multiple generations of payloads, including DNA-damaging agents, tubulin binders and topoisomerase 1 inhibitors, as well as newer payload mechanisms of action

Advancing ADCs through every stage of drug development 

Your ADC journey begins with a vision—one in which your drug candidate makes a profound impact on the lives of oncology patients. However, the path to developing these treatments is often characterized by challenges that hinder progress and delay breakthroughs.

ADCs require unique considerations for a variety of assessments, including toxicokinetics, including toxicokinetics, pharmacokinetics, efficacy, patient stratification and more. At Labcorp, we understand the complexities involved in developing ADCs given their highly nuanced chemistry. Our extensive experience delivering answers for ADC developers makes us the ideal lab partner to help you bring these treatments to market, no matter where you are in the development pipeline. 

MODEL RELEASED. Preparing sample vials. Laboratory worker pipetting liquid into an eppendorf vial. This type of equipment is used in a wide range of laboratory work, from analysis of DNA (deoxyribonucleic acid) and other samples, to medical research.

Empower your ADC therapy from Day 1 post-approval

Reach your critical milestones faster with Labcorp. We can help accelerate your ADC therapy development, stratifying target patient populations and enhancing patient care as soon as Day 1 post-approval. With our global laboratory services and resources, we offer the support needed to overcome obstacles so you can make informed decisions for your ADC program regarding:

  • Toxicity

  • Immunogenicity

  • Pharmacokinetics and pharmacodynamics

  • Payload potency and efficacy

  • Off-target effects

  • ADC characterization and stability

  • Specialized oncology biomarkers

  • Companion diagnostics (CDx) development

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Get comprehensive support for your ADC, from Discovery Through Post-Commercialization

Delivering global ADC development solutions

ADCs continue to be a widely used modality of interest for the pharmaceutical industry due to their ability to deliver cytotoxic payloads to solid tumors and blood-based malignancies that induce cell apoptosis for oncology patients. While payload and antibody types continue to evolve continue to evolve, ADCs remain challenging given their highly complex and nuanced chemistry. An ADC to be successful, the right combination of target-antigen, active linker payload, appropriate DAR, proper tumor indication and payload conjugation site need to be considered.

Navigating complexities in ADC development requires specialized global laboratory support and scientific expertise.

A mature adult physician is meeting with a patient in the patient's home. The patient is a black woman with cancer. The patient is wearing a headscarf to hide hair loss from chemotherapy treatment. The doctor and patient are seated next to each other on a couch. The doctor is holding a wireless tablet computer. The concerned patient is asking the doctor a question.

Harnessing precision in cancer therapy

ADCs have the potential to bring better outcomes for oncology patients. A global partner can offer guidance from the discovery through the post-commercialization to help bring your therapeutic through the drug development journey.

Advance your ADC therapy today with a team that has supported 83%  of all approved, on-market global ADC therapies and currently supporting 77% of ADCs in advanced clinical trial stages. 

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